| 2010/09/21 | Vointa Sibiu |  | 3-1
Pro. |  | Gaz Metan | | | | |
| | Universitatea Cluj |  | 1-0 |  | Victoria Branesti | | | | |
| | ACU Arad |  | 0-1
Pro. |  | CFR Cluj | | | | |
| | Rapid București |  | 5-0 |  | FC Petrolul Ploiesti | | | | |
| 2010/09/22 | Unirea Urziceni |  | 1-0 |  | Delta Tulcea | | | | |
| | FC Silvania Simleu Silvaniei |  | 0-1 |  | Targu Mures | | | | |
| | CS Alro Slatina |  | 0-0
(4-3
Pen.) |  | FC Vaslui | | | | |
| | Juventus Colentina Bucuresti |  | 1-3 |  | Poli Timisoara | | | | |
| | Sportul Studenţesc |  | 3-1 |  | CS Otopeni | | | | |
| | Gloria Bistrita |  | 3-0 |  | Astra Ploieşti B | | | | |
| | FC Universitatea 1948 |  | 5-0 |  | Minerul Lupeni | | | | |
| | AS Sirineasa |  | 3-2 |  | Viitorul Constanta | | | | |
| | Dinamo Bucuresti |  | 2-0 |  | FC Ceahlaul | | | | |
| 2010/09/23 | Chimia Brazi |  | 0-1 |  | Brasov | | | | |
| | Astra Ploieşti | | 2-1 |  | FC Otelul | | | | |
| | CFR Craiova |  | 0-1 |  | Steaua Bucareste | | | | |
03/05 - 15:30
03/05 - 15:45
