2019/09/07 | US Ledonienne | | 20-28 | | Palente Besançon | | | | |
| Marignane HB | | 25-30 | | US Crauroise | | | | |
| CSM Puteaux | | 28-32 | | Maisons-Alfort | | | | |
| Vitrolles HB | | 29-41 | | ASBTP Nice | | | | |
| Saint Genis Laval | | 36-35 | | Chalon-sur-Saône | | | | |
| Stade de Vanves | | 22-20 | | Lagny/Montevrain | | | | |
| Irisartarrak HB | | 28-22 | | Asson SHB | | | | |
| Loudéac HB | | 25-19 | | Saint-Malo HB | | | | |
| Entente Falaisienne | | 24-31 | | Oissel Rouen | | | | |
| Entente TUC Balma | | 32-43 | | ROC Aveyron | | | | |
| Avignon HB | | 34-20 | | Draguignan Var | | | | |
| SO Calais | | 29-27 | | Billy-Montigny | | | | |
| Meximieux HC | | 28-27 | | CS Vesoul | | | | |
| Stade Hendayais | | 22-25 | | CA Bègles | | | | |
| Segré | | 22-29 | | Saint-Cyr HB | | | | |
| Saint Priest | | 30-21 | | Vaulx En Velin | | | | |
| Tournefeuille | | 27-32 | | Bordeaux | | | | |
| AS Roissy | | 27-24 | | Stella Saint-Maur | | | | |
| Miramas HB | | 24-34 | | Guilherand-Granges | | | | |
| Orthez HC | | 19-26 | | Tardets | | | | |
| RACC Nantes | | 26-43 | | St. Nazaire | | | | |
| Bruz | | 16-43 | | PL Granville | | | | |
| SL Aubigny Moutiers Vendee | | 31-40 | | Pouzauges Vendée | | | | |
| HC Carcassonnais | | 26-36 | | AS L´Union | | | | |
| Luxeuil HB | | 24-25 | | Cernay/Wattwiller | | | | |
| Longvic | | 28-32 | | CS Vesoul | | | | |
| Hyères Olympique | | 20-23 | | SMUC Marseille | | | | |
| Eysines | | 28-35 | | Entente Charente | | | | |
| HC Marckolsheim | | 20-26 | | Lure Villers | | | | |
| Rhone Eyrieux Ardeche | | 31-28 | | Vénissieux HB | | | | |
| Cauz | | 36-31 | | Chateauneuf HB | | | | |
| Villemomble-Sports | | 39-30 | | FB2M | | | | |
| SPUC Pessac Fem. | | 27-32 | | HC Libourne | | | | |
| St. Chamond | | 34-30 | | Beaujolais | | | | |
| Pays d´Auray | | 22-31 | | Hennebont-Lochrist | | | | |
| Pays d´Aubagne | | 29-26 | | Villeneuve-Loubet | | | | |
| CAPO Limoges | | 31-35 | | HBC Objat | | | | |
| Césaire Levillain | | 23-44 | | Rouen HB | | | | |
| Gravelines | | 21-28 | | Villeneuve HB | | | | |
| Bois Colombes | | 27-38 | | Kremlin-Bicêtre | | | | |
| Bogny | | 14-17 | | Bassin Mussipontain | | | | |
| Asnières/Colombes | | 36-33 | | Issy | | | | |
| HC Volcans | | 22-38 | | Cournon d´Auvergne | | | | |
| La Seyne Var | | 28-22 | | Monaco | | | | |
| Albertiville | | 20-34 | | Annecy HB | | | | |
| Val De Gray | | 19-33 | | Beaune HB | | | | |
| Lezay | | 24-29 | | Grand Poitiers | | | | |
| HBC Semur | | 31-28 | | CL Marsannay | | | | |
| St Michel-sur-Orge | | 35-21 | | Serris Val d' Europe | | | | |
| Pays-Haut HB | | 30-38 | | Metz HB | | | | |
| Niort Soucheen | | 26-28 | | Aunis Handball | | | | |
| Neuves Maisons | | 19-29 | | HBC Villers | | | | |
| Arras | | 29-34 | | St. Polois | | | | |
| Entente Plesseene | | 36-34 | | Rueil | | | | |
| Saint-Égrève | | 33-35 | | Aix-en-Savoie | | | | |
| AS Saint-Mandé | | 24-22 | | CM Aubervilliers | | | | |
2019/09/08 | HBC Thuir | | 27-30 | | Teyran | | | | |
| Plaisir HC | | 33-40 | | Paris SC | | | | |
| Haguenau | | 21-27 | | Plobsheim | | | | |
| Lattes HB | | 26-24 | | Prades Le Lez | | | | |
| Entente Du Thelle | | 24-18 | | Stade Valeriquais | | | | |
| Le Chesnay | | 21-31 | | Saint-Ouen-L´Aumône | | | | |
| Bléré Val de Cher | | 35-23 | | Saint Pryve Olivet | | | | |
| HBC Loriol | | 33-34 | | Saint-Étienne MHB | | | | |
| Marolles Handball | | 33-39 | | Montfermeil | | | | |
| Wahagnies | | 30-29 | | Melantois | | | | |
| Thionville Moselle | | 26-31 | | Molsheim OC | | | | |
| St. Sebastien | | 22-24 | | Dreux AC | | | | |
| Romilly HB | | 25-37 | | AS Saint-Brice | | | | |
| ASB Rezé | | 22-30 | | CJB Handball | | | | |