2021/10/13 | Shenzhen FC | | 7-0 | | Shaanxi Warriors | | | | |
| Tianjin Jinmen Tiger | | 3-0 | | Beijing BSU | | | | |
| Guangzhou FC | | 0-1 | | Qingdao West Coast | | | | |
| Chongqing Dangdai | | 2-0 | | Wuhan Three Towns | | | | |
| Changchun Yatai | | 4-0 | | Zhejiang Energy Greentown | | | | |
| Dalian Pro | | 2-1 | | China S20 | | | | |
| Meixian Qiuxiang | | 1-5 | | Henan Songshan Longmen | | | | |
| Shandong Luneng | | 1-0 | | Nantong Zhiyun | | | | |
2021/10/14 | Cangzhou Mighty Lions | | 5-1 | | Zibo Cuju | | | | |
| Hebei FC | | 0-1 | | Shaanxi Chang´an | | | | |
| Wuhan FC | | 7-0 | | Dandong Tengyue | | | | |
| Guangzhou City | | 1-1 (4-5 Pen.) | | Chengdu Rongcheng FC | | | | |
| Shanghai Shenhua | | 3-0 | | Sichuan Minzu | | | | |
| Beijing Guoan | | 1-1 (2-3 Pen.) | | Sichuan Jiuniu | | | | |
| Shanghai Port | | 1-0 | | Xian Wolves | | | | |
| Qingdao Huanghai | | 3-2 | | Kunshan FC | | | | |