21/05 - 17:00
21/05 - 19:30
21/05 - 21:30
| 21-05 | 21:10 | Temperley |  | vs |  | River Plate | 1/16 | cd |
| 21-05 | 19:30 | Red Bull Bragantino |  | vs |  | Sousa | 3F | | |||
| 21-05 | 21:30 | Vasco |  | vs |  | Fortaleza | 3F | |
| 20-05 | 17:30 | Fluminense |  | 2-0 |  | Palmeiras | R11 | ||||
| 20-05 | 20:00 | São Paulo |  | 2-1 |  | Flamengo | R11 |
| 20-05 | 13:30 | Salernitana |  | 1-2 |  | Hellas Verona | R37 | ||||
| 20-05 | 15:45 | Bologna |  | 3-3 |  | Juventus | R37 |
| 20-05 | 21:00 | Guarani |  | 1-2 |  | América Mineiro | R6 | ||||
| 21-05 | 17:00 | Chapecoense |  | vs |  | Ponte Preta | R6 | |
| 20-05 | 20:00 | Floresta-CE |  | 0-2 |  | Figueirense | R5 | ||||
| 20-05 | 20:00 | Athletic-MG |  | 1-0 |  | Aparecidense | R5 |
| 20-05 | 19:00 | San Lorenzo |  | 1-1 |  | Lanús | 1F | ||||
| 20-05 | 19:00 | Estudiantes |  | 2-0 |  | Deportivo Riestra | 1F | ||||
| 20-05 | 21:15 | Racing Club |  | 3-0 |  | Argentinos Juniors | 1F | ||||
| 20-05 | 21:15 | Rosario Central |  | 1-1 |  | Tigre | 1F | ||||
| 21-05 | 20:00 | Vélez Sarsfield |  | vs |  | Newell´s Old Boys | 1F | cd |
| 21-05 | 15:00 | São José |  | vs | | Red Bull Bragantino | 1F | cd | |||
| 21-05 | 19:30 | Corinthians |  | vs |  | AD Taubaté | 1F | cd |
